Sickle cell trait and leg ulceration.

Postural vasoconstriction and leg ulceration in homozygous sickle cell disease.

1. Chronic leg ulceration is a major cause of morbidity in patients with homozygous sickle cell disease; the ulcers commonly resolve on bed rest. We have therefore compared the cutaneous vascular response to dependency in three groups of eight patients with sickle cell disease (those with an active ulcer, with an ulcer scar and with no history of ulceration) and in eight subjects with normal ha...

Leg Ulceration in Sickle Cell Disease: An Early and Visible Sign of End‐Organ Disease

Introduction: Leg ulcers are a frequent and debilitating complication of sickle cell disease (SCD), particularly of the SS genotype. The prevalence of leg ulcers in patients with sickle cell disease (SCD) varies geographically ranging widely from 75% in Jamaica to as low as 1% in Saudi Arabia. The prevalence of leg ulcers in the Cooperative Study of Sickle Cell Disease (CSSCD) in the United Sta...

Sickle cell trait.

Sickle cell trait can pose a grave risk for some athletes. In the past few years, exertional sickling has killed nine athletes, including five college football players in training. Exercise-physiology research shows how and why sickle red cells can accumulate in the bloodstream during intense exercise bouts. Sickle cells can "logjam" blood vessels and lead to collapse from ischemic rhabdomyolys...

Sickle cell trait and frostbite.

Burkitt's lymphoma and sickle cell trait.

ONLY two areas of the world, tropical Africa and New Guinea, are endemic for Burkitt's lymphoma. These are the principal areas of the world where malaria still occurs in hyperand holo-endemic forms, and within these two areas the geographical distribution of the tumour coincides closely with that ofendemic malaria. These observations suggest the possibility of a causal connection between chroni...